Toggles currently do not work with W3. It's being fixed.
It should display a message in the top left letting you know reshade has compiled effects and started properly.
Do you have that? In case you missed it on game boot you can turn on an effect and then turn it off and see if it compiles in game. Back with 1.5.1 i used to turn on borders if I couldn't tell SweetFX installed properly. You can't miss it.