It seems when SweetFX is used it kills "In-Game" support in Trillian (chat program) Is there a way make this both work together? Thank you. Windows 7 x64, Trillian 5.5 build 16

Probably not. I guess they both inject at the same place. If Crosire would've access to the source code of trillian he could fix it. But then... why should he invest time in something only 2-3 people are affected by.